DELAWARE

DISTRICT OF COLUMBIA

Protein Information Resource (Georgetown U)

MARYLAND

Bethesda
National Center for Biotechnology Info (NCBI) Structure Group

InforMax is a leading global provider of bioinformatics software solutions for the analysis and interpretation of genomic, proteomic and other biomolecular data. InforMax enables over 20,000 researchers worldwide to achieve greater insights into genetic function through biological data mining and integrated genomics analysis.

Rockville

Celera Genomic's mission is to become the definitive source of genomic, proteomics and related biological and medical information.

Protiveris, Inc., in operation since March 2000, is the result of a broad collaborative effort among leading scientists seeking to merge silicon micro-fabrication with biology to advance technology beyond the genomics revolution. The name Protiveris means "Truth in Proteins." Protiveris' mission is the development of discovery and diagnostics technologies that enable life science professionals to understand biological function at the protein level. Protiveris is strategically positioned at the crossroads of biology, chemistry and physics with a particular emphasis on bionanotechnology. Patented silicon technologies under development at Protiveris have broad applications including proteomics, molecular diagnostics and drug discovery and development.

Moult Group (Center for Advanced Research in Biotechnology)

NEW JERSEY

NJCST Initiative in Structural Genomics and Bioinformatics (Rutgers)

Piscataway

The next generation of healthcare will be built on understanding the genetic basis for disease. Amersham Pharmacia Biotech has the expertise and vision to help researchers in industry and academia to turn the promise of this molecular medicine into reality. Our biotechnology systems, (instruments, reagents and software) products and services are used in gene and protein research, drug discovery and development, and biopharmaceutical manufacturing.

Princeton

GPC Biotech AG is a leading transatlantic genomics-driven drug discovery company with a broad integrated technology platform that is unparalleled in Europe. A number of proprietary genomics, proteomics and drug discovery technologies help to accelerate the process of drug discovery and development. Alliances with leading global pharmaceutical companies validate GPC Biotech's technologies and generate revenue streams that help fund the Company's internal drug discovery projects which are focused on oncology, infectious diseases and immunology. GPC Biotech has a broad intellectual property position. In March 2000, the acquisition of the drug discovery company Mitotix, Inc. (now GPC Biotech Inc., Waltham/USA), which has world-leading expertise in cell cycle research, significantly accelerated the Company's forward integration. The combined Company realizes a common and powerful vision of integrated genomics- and proteomics-based drug discovery throughout the entire process of drug discovery, from target discovery to the clinic.

Jamesburg

Compugen develops and markets platforms, tools and products that accelerate post genomic research, the advanced study of proteins and protein pathways, and drug target discovery.

NEW YORK

Brookhaven
Brookhaven National Lab Proteome Project

Ithaca
Scheraga Lab (Cornell)

New York
Columbia University Bioinformatics Center

Darst Lab (Rockefeller U)

Kuriyan Lab (Rockefeller U)

New York Structural Biology Discussion Group

Sali Lab (Rockefeller)

Xu Lab (Sloan-Kettering Institute)

PENNSYLVANIA

Philadelphia

Ciphergen Biosystems, develops, manufactures, sells, and services ProteinChip¨ Systems and related products that discover, characterize and assay proteins from native biological samples. Ciphergen customers include many of the largest pharmaceutical and biotechnology companies worldwide, as well as government agencies, research institutions, and universities. Working with customers to develop new products and applications, Ciphergen is becoming a leader in biomarker discovery, assay development and characterization.

Newtown

AxCell is engaged in the research and development of novel biopharmaceutical products using its growing portfolio of functional proteomics solutions and collection of proprietary signal transduction pathway information. Through the systematic and industrialized measurement of protein-to-protein interactions, AxCell is assembling ProChart™, a proprietary database of signal transduction pathway information. ProChart™ currently includes pathway information for protein domain families relevant in a number of therapeutically important classes of molecules including growth factors, receptors and other potential protein therapeutics or drug targets. AxCell's database content and functional proteomics tools are available on a non-exclusive basis to biotechnology, pharmaceutical and academic researchers. AxCell is expanding and accelerating its research activities to further elucidate the role of novel proteins and pathways in ProChart™, through both external collaborations and internal data mining.

Enola

GeneFormatics Incorporated, a world leader in structural proteomics, focuses on providing novel protein function and structure information to pharmaceutical, biotechnology and agrochemical companies to accelerate the discovery of new medicines and other useful products. GeneFormatics applies its integrated, "function first," high throughput proteomics platform, which combines in silico technologies, NMR spectroscopy, X-ray crystallography and bioassays, on genomic scales to assign protein function and determine protein structure.

VIRGINIA

Herndon

Aptagen
Aptagen, Inc. is a protein sciences company specializing in genetic and proteomic manipulation through the use of our Gene Forge and Protein Genesis technology platforms. Aptagen's Gene Forge designs and builds custom synthetic genes or double stranded DNA of any size, optimizes the codon usage for maximum protein expression in the organism of your choice, is able to selectively modify a gene for proper folding and activity in a foreign host, and performs a number of other manipulations to facilitate efficient and cost effective research and product development. Protein Genesis is a highly advanced intracellular form of Directed Molecular Evolution which allows us to alter the actual structure and function of a protein of interest in order to increase primary activity and eliminate side effects of protein therapeutic drug products.

Hunt Lab (U. of Virginia)

Fairfax
Scanalytics
Scanalytics gives "sight" to computers, by creating software that captures images from digital cameras and extracts information from those images. We integrate our software into high-performance vision systems specifically to support scientific researchers in biotechnology and life sciences.

WEST VIRGINIA